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As well, MPTP, a widely used toxin, is effective in inducing Parkinsonism in both rodents and primates, based on its ability to induce persistent symptoms akin to PD in humans (Davis et al

Interestingly, a recent study examining the time-dependent effect of low IGF-1 levels on aging outcomes observed that a targeted reduction in liver-derived IGF-1 early (10 d or 5 mo) or later in life (15 mo) improved aspects of lifespan in females, though these effects were most pronounced when IGF-1 was reduced at 5 mo old 19

doi: 10.1016/j.biocel.2016.02.017

Their activity in mitophagy is regulated by phosphorylation: The phosphorylation of BNIP3 at Ser17 and Ser24 within its LIR motif is essential for LC3B interaction (86), while the phosphorylation of NIX at Ser34 and Ser35 enables it to bind with GABARAP family proteins (87)