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Unfortunately, viral gene therapy presents the risk of insertional mutagenesis and does not reliably yield high expression profiles (Monahan and Samulski, The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., in vitro and in vivo , making a strong case for a small molecule activator of HGF/c-Met to confer a neuroprotective benefit (Zhang et al., 2000

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Strategies for annulus fibrosus regeneration: from biological therapies to tissue engineering

Although theoretically this would have been expected ( vide supra ), no significant changes in intestinal calcium absorption were noted in GH-deficient patients receiving treatment with rhGH or rhIGF-1 [147]