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It was previously considered to be a specific neuroactive form of thiamine, but more recently, it has been reported that TTP (which is 10% of the total brain thiamine pool) is involved in membrane excitability and nerve conduction by acting as a modulator of the permeability of sodium chloride channels ( Intracellular Location of TPP-Dependent Enzymes Cytosol In the cytosol, TPP acts as a cofactor for TKT, a key enzyme of the non-oxidative branch of the pentose phosphate pathway (PPP)

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EngelenMKempSde VisserMvan GeelBMWandersRJAubourgPet alX-linked adrenoleukodystrophy (X-Ald): clinical presentation and guidelines for diagnosis, follow-up and management