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Who Is the Right Candidate for Tesofensine

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It is not possible to reliably determine whether T291 or T292 are phosphorylated by LRRK2 as alanine mutations of one site most likely impact the phosphorylation motif of the other site, whereas definitively resolving phosphorylation sites between adjacent identical residues (i.e., pTT or TpT) in a single phospho-peptide by mass spectrometry is not possible