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When the gene expression was examined, in vitro treatment of the human stem cell-derived neurons showed decreased expression of GRIA1, GRIA2, GRIN2A, and GRIN2B genes [73]

However remaining enough complicated, inspection of these equations is done first analytically and reveals the existence of a simple homogeneous solution which allows a linear perturbation analysis as commonly done in nonlinear physics

The protection of the nervous system was also confirmed in mouse models of Alzheimers disease, as well as in mouse and zebrafish models of ataxia (MachadoJoseph disease)

In animal models, this pathway has been proposed as a contributor to observed changes in tissue vascularization at injury sites