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References 135 and 288 describe model systems to assess response to CFTR modulators in vitro by either using intestinal organoids or skin-derived pluripotent stem cells transformed into airway epithelial cells, respectively

Increased ROS levels modulate transcription factor activity, especially NF-B, activator protein-1 (AP-1) and the peroxisome proliferators-activated receptor (PPAR) family of transcriptional activators (Elahi et al., 2009)

The plate was stirred briefly and laccase activity was determined following the absorption of ABTS oxidation at 418 nm ( of ABTS + = 36,000 M 1 cm 1 ) in kinetic mode using a plate reader SpectraMax ABS Plus (Molecular Devices)

Laposky AD, Bass J, Kohsaka A, Turek FW