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However, the experimental data exhibits and offset of 6% corresponding to an analgesic effect in the absence of drug administration that cannot be explained by the paradigm of an increase in anionic current

The nasal septum supports targeted local drug application, while the nasopharynx contributes to the onward transport of inhaled/deposited material (Jeong et al., 2023)

Therefore, ZIL may adequately dehydrate the cells to prevent intracellular ice formation like other non-cell-permeable cryoprotectants 20,21,22

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