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10.1016/j.jpain.2017.11.013 84 SerraJ.ColladoA.SolR.AntonelliF.TorresX.SalgueiroM.et al

39,40,41,42 This process requires an active escort mechanism, whereby the AAA+ ATPase p97/valosin-containing protein (VCP) (known as Cdc48 in yeasts) extracts misfolded, damaged, or improperly synthesized proteins from the ER to enable their recognition and processing by ER-dedicated E3 ubiquitin ligases, which mark them for degradation by the 26S proteasome