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16,326 In conditions of nutrient excess, as seen in T2DM, insulin resistance blunts insulin-mediated nutrient and energy responses, impairing nerve metabolism and bioenergetic failure

doi: 10.1016/j.rbmo.2017.08.018 [DOI] [PubMed] [Google Scholar] 225

It was known for many years that several electrophilic xenobiotics (e.g., phenacetin, acetaminophen, and N -hydroxy-2-acetylaminofluorene) are thiomethylated in vivo