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2272-C ACCELERATION OF AN ADVANCED NASH MODEL BY ACUTE AND TOXIC EFFECTS OF PHENOBARBITAL Nico Kraus 1 , Magnus Moeslein 1 , Robert Schierwagen 1,2 , Wenyi Gu 1,2 , Maximilian Joseph Brol 1,2 , Frank Erhard Uschner 1,2 , Pierre-Emmanuel Rautou 3,4 , Sophie Lotersztajn 5,6 , Roger Flores-Costa 7 , Joan Claria 7,8 , Jonel Trebicka 1,2,8 and Sabine Klein 1,2 , (1)University Hospital Frankfurt, (2)University Hospital Mnster, (3)Hpital Beaujon, (4)Universit Paris-Cit, (5)Inserm, (6)Sorbonne Paris Cit, (7)Hospital Clnic-Idibaps, Barcelona, Spain, (8)European Foundation for the Study of Chronic Liver Failure Background: Non-alcoholic steatohepatitis (NASH) is an increasing cause for liver cirrhosis globally