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The epidemiology of coexisting iodine and selenium deficiencies in central Africa, but not in China, has been linked to myxedematous cretinism, a severe form of congenital hypothyroidism accompanied by mental and physical retardation

Losses may be measured, detected and/or diagnosed in any of the many ways known to those of ordinary skill in the art

Current theories concerning disease pathogenesis include an imbalance between protease and anti-protease activity, induced apoptosis of alveolar cells through deregulation of pathways involved in oxidative stress, chronic inflammation, and aberrant tissue remodeling that lead to the destruction of the extracellular matrix (ECM) in the lung [3, 4]

PubMed Central PMCID: PMC5806803 10.1177/0394632017736674 [DOI] [PMC free article] [PubMed] [Google Scholar] 134.Anand David A.V., Arulmoli R