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dollars Nicotine Mechanism Of Action Absorbed via oral mucosa, lungs, GI mucosa, and skin Rapidly Distributes Throughout Body Cholinergic Receptor Agonist Dose Dependant Response Acts on CNS and Peripheral Nervous System Metabolized via the lung and liver NICOTINE PHARMACODYNAMICS: WITHDRAWAL EFFECTS Depression Insomnia Irritability/frustration/anger Anxiety Difficulty concentrating Restlessness Increased appetite/weight gain Decreased heart rate Cravings* Most symptoms peak 2448 hr after quitting and subside within 24 weeks

Compared to placebo, varenicline increased the odds of smoking cessation and was superior to both NRT and bupropion

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Hao et al., 2023)