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Philos Trans A Math Phys Eng Sci 368, 439454 (2010)

The other 70 patients had a delayed diagnosis and treatment, with an average of 9 years since infection

However, despite low intra-portal insulin levels, low IGF-I and increased fat mass and decreased lean body mass, their glucose tolerance and insulin sensitivity remains unaffected and in fact, is comparable to normal controls (151, 152)