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Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria

Based upon the data in the study, we propose that CVS is likely the result of cellular hyperexcitability, as a result of a vicious cycle of elevated intracellular cations and mitochondrial dysfunction (Figure 1)