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Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

10.1016/j.cnp.2017.07.001 34

Recent research has identified several adaptive mechanisms through which red blood cells regulate oxygen delivery, including NO-driven changes in membrane deformability, Cys93-dependent S-nitrosylation, adenosine-mediated stimulation of glycolysis and 2,3-BPG production, and the formation of hypoxic memory via degradation of eENT1 (Peng et al., 2019