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DFO upregulates GPX4, xCT, and GSH, curbs gliocyte overgrowth, enhances long-term motor function, and mitigates iron overload (Yao et al., 2019)

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Figure 11 Autoimmunity Upregulation of autoimmune genes As in other chronic disorders, some genes in ME/CFS patients have been found to be associated with autoimmunity, such as the HLA alleles (88), along with two other variants of HLA-DQB1 in combination with two RAGE-374A variants (489) was found

Nearly 150 mutant forms of SOD1 have been identified in ALS patients, which are responsible for approximately 20% of all the inherited cases [117]