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3.2 Core antioxidant enzymes were reprogrammed in a stage- and cultivar-dependent manner We first profiled genes encoding the core antioxidant enzymes that constitute the primary defense against ROS SOD s, CAT s and GPX s ( Figure 2 , Supplementary Figure S2 )

Therefore, it is likely that inflammatory mediators are responsible for the synthesis/turnover of several types of GABA A receptors

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Importantly, some reports indicate that Nrf2 agonists, such as sulforaphane, marliolide, and its derivative, 5-methyl-3-tetradecylidene-dihydro-furan-2-one (DMF02), have the potential to be used in the treatment of hyperpigmentation disorders [36, 38], although additional clinical studies are required