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A Category 1 designation can be resolved in either direction: the FDA may determine the compound is appropriate for compounding (moving it to an approved list) or inappropriate (moving it to Category 2)

The highest resolution achieved in cryo-EM for protein structure determination is currently 1.25 (as reported for apoferritin, which is composed of 24 subunits arranged in a symmetrical structure, with a total molecular mass of 440480 kDa) (Yip et al., 2020)

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