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Description

Bell TJ, B O, Morgan DJ, Salek-Ardakani S, Jagger C, Fujimori T, et al

Individual mice ranged from 51 to 191 days of age

The second allosteric site is formed by the deep groove between the catalytic domain and the dimerization domain

This network connects peripheral dysregulation to central neurodegeneration, demonstrating that PD etiology goes beyond local brain pathology to include systemic immunological and metabolic interactions