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The ECM not only determines tissue structure but also regulates many cellular processes through determining the bio-availability of cytokines, chemokines and growth factors, 85,86,87 and by directly influencing the migration and activation of cells 83,88 hence influencing immune responses

Moreover, it contributes to the brain's protection against oxidative degeneration by elevating glutathione levels, a crucial antioxidant, by amplifying c-glutamyl transpeptidase gene expression [29]

H 2 O 2 was obtained from Roth

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