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Figure 2 shows health care expenditures for obese individuals, current smokers, past smokers, heavy drinkers, and people who have aged from 30 to 50, as compared with a baseline of normal-weight individuals of the same age and sex with similar social demographics

This variability in study designs may pose challenges in establishing causation and generalizing findings to broader populations

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For example, some antidepressants like amitriptyline (Elavil), doxepin (Sinequan), and imipramine (Tofranil) are muscle relaxants and could cause transient LES relaxations