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Bioinformatics analysis and gene expression profiles from inflammatory cell models revealed that overexpression of FDFT1 significantly reversed the inflammatory response and apoptosis of BV2 cells induced by heme

10.7555/JBR.37.20220249 9

Attardi LD, Donehower LA

Unlike -KG, abnormal accumulation of succinate and fumarate in tumor tissues represses PHD, thus reducing HIF1 hydrolysis, suppressing demethylation of DNA and histones, and promoting the occurrence and development of tumors (Cavalli and Heard, 2009