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The approach harbours significant potential to detect prodromal individuals prior to diagnosis to identify pathologically defined subgroups of people with Parkinsons disease, and to establish biomarker-defined at-risk cohorts

Early phase response (weeks 1-2) Initial responses to combination therapy typically manifest as reduced inflammation and pain at injury sites

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12% of participants continued losing weight through week 48 without reaching plateau 8% of participants experienced early plateau before week 36, then maintained successfully 80% of participants reached plateau between weeks 36-48 as expected The plateau phase shows Retatrutides maintenance value