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Importantly, within 1 hour from dTAG V -1 administration, most of METTL9-FKBP-FLAG was degraded in mESCs, as shown by WB (Fig

Metabolic analysis revealed significant increases in the concentration of several metabolites known to be beneficial in the treatment of autoimmune diseases, including acetyl-CoA, ascorbic acid, citrate, butyryl-CoA, glutathione, glycoursodeoxycholic acid (GUDCA), and acetic acid, while significant decreases were observed in isoleucine and urea, among others (Supplementary Table 2)

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It should also be noted that the actual amounts of hydroperoxy-phospholipids formed after IL-13 treatment may be even greater if one accounts for the electrophilic secondary products of hydroperoxy-phospholipid decay that attack the nucleophilic sites of proteins and form covalent adducts