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But I am going to walk you through what it actually is, how it works differently from cortisone, what the research says, and what the complete treatment pathway looks like at my practice from the first conservative steps all the way through regenerative medicine and, when truly necessary, surgery

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Regardless, patients with TDP-43 mutations have TDP-43 pathology, and the mouse model that have A315T mutation has TDP-43 accumulations mostly in the nucleus, have extensive ubiquitinated protein accumulations in the cytoplasm, and based on the antibody used, pTDP-43 are also detected in the cytoplasm 19,46