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It uses a synthetic peptide corresponding to the final 24 C-terminal residues of the E-domain variously written as MGF-Ct24E, MGF-24aa-E, or simply the MGF peptide. This distinction is critical and frequently blurred: when the literature reports that MGF activates satellite cells or promotes myoblast proliferation, it is almost always referring to this isolated E-domain peptide, not to the intact spliced protein that carries a functional IGF-1 core

The resulting signal complexes initiate a variety of different signal transduction pathways and expand information to activate a series of intracellular biochemical reactions or integrate different information to introduce synthetic reactions, such as cell proliferation

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