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Figure 4 8 Translational outlook: analogs, safety liabilities, and delivery strategies Erastin has demonstrated antitumor activity in several malignancies, including gastric and colorectal cancer (69, 70), and the inflammatory, iron-loaded, oxidative microenvironment shared by many tumors and EMS provides a coherent theoretical basis for applying this strategy to EMS (71, 72)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo : insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression

Then, cancer cell invasion into LVs is facilitated by the high interstitial fluid pressure inside the tumor (138) ( Figure 4A )

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