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Mutations in Plasmodium falciparum Kelch13 (PfK13) dysregulates PI3K/AKT signaling pathway in artemisinin resistance

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promotion of a tolerogenic rather than pro-inflammatory environment), T- and B cells among others, as well as their ability of expressing the enzyme 25-(OH)-D-1-hydroxylase (CYP27B1 allele), thus influencing innate and adaptive immunity, including B-cell-mediated humoral defense [108, 151, 170,171,172,173,174,175]