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When IGF-1 binds to its receptor, two major signaling pathways are activated: the mitogen-activated protein kinase (MAPK) pathway and the phosphatidyl inositol 3-kinase/protein kinase B (PI3K/AKT) pathway, both having critical effects on IGF-1-induced cell growth, survival, migration and proliferation (Yin et al

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The specific activity was calculated from the final protein concentration (1.3 nM g protein -1 min -1 ) in the reaction mixture

Sur le plan visible, cela se traduit par une peau qui rsiste mieux aux agressions quotidiennes : moins de tiraillements, une texture plus rgulire, moins de marques de fatigue