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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E

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FTIR analysis demonstrated distinct spectral shifts indicative of interactions between DNAzyme molecules and phospholipid bilayers, thereby verifying the effective incorporation of DNAzymes into the liposomal structure

2.9.2 Nerve conduction test Twelve weeks post-surgery, to evaluate nerve regeneration, compound muscle action potential (CMAP) amplitudes of the sciatic nerves were evaluated [36]