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Compared to sorafenib, sintilimab plus a bevacizumab biosimilar (Sint-IBI305) showed the greatest OS benefit (HR=0.57, 95% CI=0.430.75, P score=0.944), followed by camrelizumab plus rivoceranib (Cam-Rivo

The concept of neuroprotective (A2-type) and neurotoxic (A1-type) reactive astrocytes reflects dynamic transitional states within a continuum of the same astrocyte lineage, rather than fixed subtypes