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Approximately three quarters of these patients have other clear signs and symptoms of central nervous system involvement, occasionally with onset and progression in the teenage years (71

doi: 10.1016/j.phrs.2021.105694 101 LiB.DuP.DuY.ZhaoD.CaiY.YangQ.et al

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As anticipated, the dissection of apparent equilibria into elementary redox ones in biological thiol-disulfide systems reveals significant differences between reactions of apparently highly similar, covalently identical reactants, improving thus our understanding of redox homeostasis and providing new means to influence it