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Furthermore, persistent inflammasome activation also disrupts autophagic regulation in glial cells, impairing the clearance of aggregated proteins and contributing to the loss of neuroimmune homeostasis [162, 163, 164]

Furthermore, the top 10 down regulated metabolites were Eicosapentaenoic acid, 1,4-Benzothiazine-O-quinonimine, Irilone de Iris, Hovenidulcioside B1, 2-Methyl-3-hydroxyphenylpropionic acid, Propionylcholine, cis-4- Hydroxycyclohexylacetic acid, N-Phenyl-1-naphthylamine, Coumarin, and 5,7,4-Trihydroxy-3-methoxyflavanone 4-O-isobutyrate metabolites (Figure 3B)

It is contraindicated in people receiving chemotherapy medications, anti-psychotic medications or pregnant/breastfeeding

Patients with MASH exhibit increased Th2/Treg and Th17/Treg ratios in peripheral blood compared to healthy controls, and the hepatic Th17/Treg ratio is also elevated (135, 136)