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Akinyemi et al

Revised: April 2023 Alcon Distributed by: Alcon Laboratories, Inc

Activation of SKN-1 via mutation of the histidine catabolism pathways results in increased oxidative stress resistance at the cost of decreased resistance to heat stress indicating that SKN-1 mediates a tradeoff between stress response survival

A Multi-Modal Approach to Desensitization The concept of desensitization has been expanded from only targeting alloantibody (IVIG/IA/plasmapheresis) to instead targeting the upstream sources of antibody such as B cells (Rituximab) and PC (proteasome inhibitor)