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When the incident radiation (gamma rays, X-rays) impinges on a Au NPs, the NPs becomes a new source of radiation and emits high energy through scattered photons (X-rays), photoelectrons, Compton electrons, Auger electrons, electronpositron pairs and fluorescence photons, thereby causing radiochemical (free radicals and ionization) damages to the surrounding tumor tissue 22,24,25

Disease states that affect intra-portal insulin levels by increasing insulin resistance causing compensatory intra-portal hyperinsulinemia or by decreasing pancreatic -cell insulin secretion causing intra-portal hypoinsulinemia results in changes to hepatic IGF-I synthesis and secretion, and consequently changes in GH levels via the negative feedback loop

Following CAR T-cell infusion, patients experience B-cell depletion lasting weeks to months