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Specifically, moderate DNA damage stress triggers mitophagy to remove damaged and depolarized mitochondria, while drastic stress is able to induce mitochondrial outer membrane permeabilization and apoptosis [174]

Moreover, the majority of the itaconated secreted proteins (70%) are annotated as secretory proteins 36 , suggesting that PBSP also has high specificity for protein secretion (Fig

For instance, emerging research suggests that elevated body fat percentage in conjunction with low lean muscle masscalled sarcopenic obesityis associated with poor kidney-related health outcomes

L-carnitine transports fat from these deposits, releasing it for the metabolism to burn