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In particular, for neuroendocrine PCa (NEPC), it uncovered potential antigens by leveraging the Isoform peptides derived from RNA splicing through the Immunotherapy target Screening (IRIS) platform (Pan et al., 2023)

Loading Phase (Weeks 1 through 4) Tb-500: 2 to 2.5 mg twice weekly (Monday and Thursday) totaling 4 to 5 mg per week Bpc-157: 0.5 mg daily, either as single dose or split into 0.25 mg twice daily Maintenance Phase (Weeks 5 through 8 plus) Tb-500: 2 mg once weekly Bpc-157: 0.25 to 0.5 mg daily Critical Notes Use separate vials and syringes for each peptide Never mix Bpc-157 and Tb-500 in the same syringe Tb-500 can be injected anywhere subcutaneously Bpc-157 should ideally be injected near the injury site The critical implementation detail bears repeating: Bpc-157 and Tb-500 should never be combined into a single vial as peptides lose their effectiveness when mixed incorrectly