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The risks of laser surgery include transient hyperpigmentation or hypopigmentation, slight scarring, permanent hyperpigmentation, incomplete clearance, and especially recurrence

However, the specific gaps remain unanswered regarding which metabolic pathways are involved during the efferocytosis of infected ACs, which could maintain the immunogenic phenotype to clearance the infection, and these remain poorly explored

These challenges span from accurately identifying the right patients, to delivering therapy precisely to the liver, to safely engaging novel molecular targets, and finally, to demonstrating efficacy in rigorous trials

Oral bioavailability for most peptides hovers around 1 to 2 percent