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New-onset Kayser-Fleischer rings on slit-lamp exam (an ophthalmologic finding indicating corneal copper deposition, though exceedingly unlikely at therapeutic GHK-Cu doses)

In Marfan mice, NOX4 deficiency results in delayed aortic aneurysm progression and normalization of endothelial dysfunction in Marfan aorta (89)

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New techniques such as 3D and speckle-tracking echocardiography (STE) provide further insights into heart function, showing that Global Longitudinal Strain (GLS) may be a better prognostic indicator than EF (41)