Inhibition of THBS-1 expression can activate the PI3K/AKT pathway (236)
Elevated intracellular cAMP then drives the following cascade, as characterised in Mel-Ab and B16 melanocyte cell line preparations: MC1R cAMP PKA CREB phosphorylation MITF upregulation tyrosinase expression Picture it this way: MT1 docks at the extracellular binding pocket of MC1R, triggering a conformational shift that couples the receptor to the Gs protein
Front Pharmacol 12:762654 Alaaeldin R, Mohyeldin RH, Sharata EE, Attya ME, Fathy M (2024) Vincamine exerts hepato-protective activity during colon ligation puncture-induced sepsis by modulating oxidative stress, apoptosis, and TNF/Nrf-2/Keap-1 signaling pathways
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