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J Neurochem 97:1634-1658 Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL (2009) Glutathione dysregulation and the etiology and progression of human diseases

Inpatient Infusion Protocol In the inpatient setting, a continuous ketamine infusion can be initiated at 0.1 mg/kg/h and increased by 0.05 mg/kg/h hourly up to a rate of 0.25 mg/kg/h or until pain relief, nystagmus, or mild inebriation occurs

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Substrate (e.g., glucose) consumption and oxygen consumption continue, and will actually increase, because the protons are not being pushed out against a gradient and just flow right back in without doing any work to make ATP