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Peoples JN, Saraf A, Ghazal N, Pham TT, Kwong JQ

NAD+ (nicotinamide adenine dinucleotide) is a critical cofactor for mitochondrial energy production and sirtuin activationproteins that regulate cellular aging, inflammation, and fat metabolism

How Glutathione Works Glutathione competitively inhibits melanin synthesis in the reaction of tyrosinase and L-DOPA by interrupting L-DOPA's ability to bind to tyrosinase during melanin synthesis

Results Confirmation of de- and subsequent remyelination in the standardized CPZ model in C57BL/6 mice To standardized the CPZ model, we used young adult male C57BL/6 mice aged 8-weeks for CPZ feeding at a dose of 0.2%(w/w) in all experiments (Hiremath et al., 1998).Before tracking OL lineage cell dynamics in this standardized CPZ model, we first confirmed and mapped out a detailed time course with mainly 1-week intervals for the CPZ-induced demyelination and subsequent remyelination after drug withdrawal, with the whole course lasting up to 9 weeks, as shown in the diagram in (Fig.1A)