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A RCT showed that daily supplementation with 10.78 g of collagen peptide (COLLinstant ) for 6 months could significantly reduce the VAS pain score of knee OA patients (an average reduction of 43.6%, p 70) should be restricted to maintain post-meal blood glucose below 7.8 mmol/L (152)

cAMP/PKA Steroidogenic Signalling In primary mouse Leydig cell cultures, hCG was found to be approximately 10-fold more potent than LH in cAMP recruitment, and slightly but significantly more potent in cAMP-dependent Erk1/2 phosphorylation though no significant differences were observed at the level of downstream steroidogenic events including Creb phosphorylation, Stard1 gene expression, and testosterone synthesis

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