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2) ROS as a selectable trait: oncogenic signaling and adaptation While ROS-induced genomic instability is a well-established driver of initial malignant transformation [82,83,84,85,86,87,88,89,90], the role of redox signaling shifts dramatically in established tumors

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PrimeView Published: Meniere's disease Nature Reviews Disease Primers volume 2 , Article number: 16029 (2016) This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 1 digital issues and online access to articles $119.00 per year only $119.00 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF