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mRNA-based therapeutics-developing a new class of drugs

doi: 10.1007/s00424-018-2147-7 64 PerrySFMcNeillBEliaENagpalAVulesevicB

PHD activates the pseudohypoxic response by stabilizing HIF-1, which is a well-known tumorigenesis enhancer, and as a transcription factor, maintains the metabolic reprogramming of cancer cells to support their survival 127