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Lower doses of the nanoparticle-based formulation showed enhanced efficacy, with in vivo toxicity studies confirming its safety at the tested levels (466)

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Cognitive deficits Researchers in a mouse study from 2016 found that SS-31 administration after isoflurane treatment effectively rescued cognitive deficits by reversing mitochondrial dysfunction in the hippocampus, the part of the brain responsible for memory and learning.7 This reversal, in turn, helped regulate the signaling of brain-derived neurotrophic factor, an essential protein for neuronal function.5 In a 2017 study, researchers administered SS-31 to young rats before isoflurane treatment to examine its utility as a preventive against cognitive defects

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