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doi: 10.1016/j.taap.2011.05.013 2 AguiarC

It occurs if symptoms such as vasoconstriction, increased OS, coagulation cascade, high LDH levels, pulmonary-renal syndrome (PRS), and hyperhomocysteinemia are present

The effects of a ketogenic diet on patients with dihydrolipoamide dehydrogenase deficiency

6.4 Extrinsic Aging While all tissues undergo intrinsic aging, the skin is also uniquely subject to extrinsic aging resulting from extensive exposure to environmental factors