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doi: 10.1021/acsnano.4c18345 118 ZhuDLuoLZengHZhangZHuangMZhouS

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Moreover, although the unmethylated CpGs of lipoplex systems are masked preventing an innate immune response, once they are in the general circulation, lipoplex systems may be, similarly like polyplex systems, opsonized by blood proteins (C3, IgG, lipoproteins and fibronectin) resulting in inflammatory reactions (mediated by TNF-alpha, IL-6 and IL- 12) in lungs and liver

In contrast to the X-ray irradiation response, the repair kinetics was similar between the two cell lines