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doi: 10.1111/micc.12117, 18

B.NevesM.IonitaA.GerivazR.et al (2024)

Compounding opens the full matrix: tretinoin at any strength (0.0250.1%) paired with clindamycin, niacinamide (45% for barrier support), azelaic acid, or dapsonein a vehicle selected for the patients skin type

However, excessive NADPH accumulation impairs the Keap1-Nrf2 pathways adaptive response to oxidative stress and overloads the thioredoxin (Trx) system