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In the first example ( A ), there is no movement of drug out of the beaker, so the graph shows only a steep rise to a maximum followed by a plateau

However, these resulting effects of NRF2 induction via CDDO treatment were to a dramatically lower degree compared to the effects of NRF2 induction upon GSH depletion in Gclc L-KO mice (Figs

Glutathione is also an integral part of the bodys antioxidant defense system, so other parameters need to be considered in conjunction with glutathione levels: Glutathione is made up of three amino acids that are combined to create a peptide that behaves as a powerful antioxidant and also has several crucial roles in the body

Pandit A, Vadnal J, Houston S et al (2009) Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosis